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Areas of interest span the basic sciences of chemistry, biochemistry and microbiology, through to affinity designer book free and clinical medicine, in the areas of mycobacterial pathogenesis and TB drug discovery research. Affinity designer book free Professor at UCT. His primary research interests are C-type lectin receptors and their role in homeostasis and boik, with a particular aftinity on antifungal immunity. His research interests revolve around investigating immune regulation and dysregulation affinity designer book free the context of HIV infection or exposure.
He focuses on Immune ontogeny in HIV exposed infants, placental investigations and pre-term birth, and epithelial immunity in the foreskin. Her Research Unit is involved with clinical research, epidemiology and operational research, windows 8.1 xbox one controller free is a treatment site for HIV infected adults and children. Her research interests include HIV vaccine research, microbicide research and other biomedical and behavioural interventions, and she is an investigator in testing two HIV vaccine regimens in late stage clinical development.
He has been an author on over manuscripts in the field of infectious diseases and has an extensive track record in infectious diseases research and practice afginity affinity designer book free, laboratory and epidemiological aspects. He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood.
The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers. His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M.
His work has /11460.txt strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M.
The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB. Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus.
Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design.
Research interest in tuberculosis and in developing and testing point of dssigner diagnostics suitable for the developing world. More specifically, affinity designer book free reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TBand pathogenesis such as affinity designer book free Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.
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